Novel regioselective ester hydrolysis by pig-liver esterase

Basak, Amit ; Bhattacharya, Gautam ; Palit, Sunanda K. (1997) Novel regioselective ester hydrolysis by pig-liver esterase Bulletin of the Chemical Society of Japan, 70 (10). pp. 2509-2513. ISSN 0009-2673

Full text not available from this repository.

Official URL:

Related URL:


Pig-liver esterase, which catalyzed the hydrolysis of substrates containing both saturated and α,β-unsaturated/cyclopropanecarboxylic esters (methyl and ethyl), was studied. An exclusive hydrolysis of the saturated esters was observed. Kinetic experiments revealed that the presence of deactivated carbonyl in the unsaturated/cyclopropanecarboxylic esters and their weaker bindings are both responsible for the observed specificity. The relative binding abilities of the substrates have been explained in light of Jones active-site model. The regioselectivity has been exploited in the synthesis of intermediates for the thromboxane synthetase inhibitor.

Item Type:Article
Source:Copyright of this article belongs to Chemical Society of Japan.
ID Code:1694
Deposited On:05 Oct 2010 12:07
Last Modified:05 Oct 2010 12:07

Repository Staff Only: item control page