Surface behavior of prostaglandins (PGs)

Colacicco, Giuseppe ; Basu, M. K. (1978) Surface behavior of prostaglandins (PGs) Prostaglandins, 16 (2). pp. 189-205. ISSN 0090-6980

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This study establishes some correlations between molecular structure and surface function of six prostaglandins in a model membrane system. Using spread films at the air/water interface, we determined surface pressure and surface potential of PGs A1, A2, E1, E2, F and F. All the PGs formed films with low pressure (0 to 9 dyne/cm) and relatively low surface potentials (ΔV = 10 to 250mV). On 0.15M NaCl, the ∏ and ΔV values were in the order E1 > F > A1 > F > A1 > F = A2 > E2 and F > E1 > A1 > A2 > F > E2 respectively. Clearly, the cis unsaturation in the carboxylic chain of the PG2 series conferred greater instability to the films, as indicated by the lowest Π and ΔV values. Also, members of the PG1 series penetrated films of dipalmitoyl phosphatidyl choline (DPPC) better than PG2 did, the ablest being E1 (ΔΠ = 12 dyne/cm) and the poorest F (ΔΠ = 2 dyne/cm); penetration of E1 and F was independent of the initial pressure (Πi) of the DPPC film, whereas with A1 and F ΔΠ decreased as Πi increased. The PGs expressed marked discriminating capacities for the electrolyte, as indicated by differences in their Πand ΔV responses to Na+ and Ca++ as well as for the lipid, as indicated by different penetration (ΔΠ values) into DPPC films.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
ID Code:1693
Deposited On:05 Oct 2010 12:07
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