Why is transcription coupled to translation in bacteria?

Gowrishankar, J. ; Harinarayanan, R. (2004) Why is transcription coupled to translation in bacteria? Molecular Microbiology, 54 (3). pp. 598-603. ISSN 0950-382X

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Official URL: http://onlinelibrary.wiley.com/doi/10.1111/j.1365-...

Related URL: http://dx.doi.org/10.1111/j.1365-2958.2004.04289.x


Active mechanisms exist to prevent transcription that is uncoupled from translation in the protein-coding genes of bacteria, as exemplified by the phenomenon of nonsense polarity. Bacterial transcription-translation coupling may be viewed as one among several co-transcriptional processes, including those for mRNA processing and export in the eukaryotes, that operate in the various life forms to render the nascent transcript unavailable for formation of otherwise deleterious R-loops in the genome.

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