Dey, Bappaditya ; Jain, Ruchi ; Khera, Aparna ; Rao, Vivek ; Dhar, Neeraj ; Gupta, Umesh D. ; Katoch, V. M. ; Ramanathan, V. D. ; Tyagi, Anil K. (2009) Boosting with a DNA vaccine expressing ESAT-6 (DNAE6) obliterates the protection imparted by recombinant BCG (rBCGE6) against aerosol Mycobacterium tuberculosis infection in guinea pigs Vaccine, 28 (1). pp. 63-70. ISSN 0264-410X
Full text not available from this repository.
Official URL: http://linkinghub.elsevier.com/retrieve/pii/S02644...
Related URL: http://dx.doi.org/10.1016/j.vaccine.2009.09.121
Abstract
Owing to its highly immunodominant nature and ability to induce long-lived memory immunity, ESAT-6, a prominent antigen of Mycobacterium tuberculosis, has been employed in several approaches to develop tuberculosis vaccines. Here, for the first time, we combined ESAT-6 based recombinant BCG (rBCG) and DNA vaccine (DNAE6) in a prime boost approach. Interestingly, in spite of inducing an enhanced antigen specific IFN-γ response in mice, a DNAE6 booster completely obliterated the protection imparted by rBCG against tuberculosis in guinea pigs. Analysis of immunopathology and cytokine responses suggests involvement of an exaggerated immunity behind the lack of protection imparted by this regimen.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Tuberculosis; ESAT-6; Prime Boost Vaccination |
| ID Code: | 16859 |
| Deposited On: | 16 Nov 2010 13:26 |
| Last Modified: | 04 Jun 2011 06:42 |
Repository Staff Only: item control page
