Drug delivery system: targeting of pentamidines to specific sites using sugar grafted liposomes

Banerjee, Goutam ; Nandi, Gopa ; Mahato, Sashi B. ; Pakrashi, Anita ; Basu, Mukul K. (1996) Drug delivery system: targeting of pentamidines to specific sites using sugar grafted liposomes Journal of Antimicrobial Chemotherapy, 38 . pp. 145-150. ISSN 0305-7453

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Official URL: http://jac.oxfordjournals.org/cgi/content/abstract...

Abstract

Different sugar-grafted liposomes were prepared and tested against experimental leishmaniasis in vivo using the classical drug pentamidine isethionate and its methoxy derivative. Both the drugs, when encapsulated in sugar-grafted liposomes were found to be more potent in comparison to normal liposome-encapsulated drug or to the free drug. Moreover, the mannose-grafted liposomes were adjudged to be the best in lowering of spleen parasite load in comparison with those bearing glucose or galactose. When encapsulated in mannose-grafted liposomes the therapeutic efficacy of pentamidine isethionate was found to be better than that of its methoxy derivative, although the latter seemed to be less toxic than the pentamidine isethionate itself.

Item Type:Article
Source:Copyright of this article belongs to Oxford University Press.
ID Code:1680
Deposited On:05 Oct 2010 09:47
Last Modified:16 May 2016 12:45

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