Singh, Anita ; Singh, Sanjaya ; Kanungo, M. S. (1990) Conformation and expression of the albumin gene of young and old rats Molecular Biology Reports, 14 (4). pp. 251-254. ISSN 0301-4851
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Official URL: http://www.springerlink.com/content/g66034857p2573...
Related URL: http://dx.doi.org/10.1007/BF00429893
Abstract
The conformation and expression of the albumin gene in the liver of young (21-) and old (85-week) rats were studied. Digestion of nuclei with MNase shows no differences in the nucleosomal organization in the coding region of the gene in the two ages. The gene has a DNase I hypersensitive site which is distinctly less sensitive in old rats. Its 5'-CCGG-3' sequences are more methylated in the old in which its rate of transcription is also lower.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Springer-Verlag. |
| Keywords: | Aging; Nucleosomal organisation; DH-site; CCGG-methylation |
| ID Code: | 16501 |
| Deposited On: | 15 Nov 2010 09:32 |
| Last Modified: | 03 Jun 2011 09:02 |
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