Gandhi, Behrose S. ; Kanungo, M. S. (1974) Modulation of malate dehydrogenase of young and lod rats by various effectors Experimental Gerontology, 9 (4). pp. 199-207. ISSN 0531-5565
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/053155...
Related URL: http://dx.doi.org/10.1016/0531-5565(74)90037-0
Abstract
Malate dehydrogenase was partially purified from the skeletal muscle and brain of young and old mate rat. The Km (oxalacetate) values of both the enzymes are significantly higher in old age. Citrate and G-1-P inhibit the enzyem of both the organs non-competitively, and ATP inhibits it uncompetitively at both the ages. These inhibitory effects are significantly lower in old age. This change in regulatory function may be of disadvantage in olf age.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 16374 |
| Deposited On: | 15 Nov 2010 13:46 |
| Last Modified: | 03 Jun 2011 09:27 |
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