Thakur, M. K. ; Kanungo, M. S. (1981) Methylation of chromosomal proteins and DNA of rat brain and its modulation by estradiol and calcium during aging Experimental Gerontology, 16 (4). pp. 331-336. ISSN 0531-5565
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/053155...
Related URL: http://dx.doi.org/10.1016/0531-5565(81)90052-8
Abstract
The effects of estradiol and calcium on in vitro methylation of histones, NHC proteins and DNA of the cerebral cortex of rats of different ages were studied. Methylation of histones and NHC proteins decreases with age. Estradiol and calcium stimulate methylation of histones in immature and adult rats. Estradiol enhances methylation of NHC proteins only in the adult, whereas calcium inhibits it in immature and adult rats. Methylation of DNA increases with age. It is inhibited by estradiol, but is stimulated by calcium. Such age-dependent changes in methylation of chromosomal proteins and DNA, and their differential modulation by different effectors may destabilize the expression of genes and cause aging.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 16358 |
| Deposited On: | 15 Nov 2010 13:47 |
| Last Modified: | 03 Jun 2011 09:08 |
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