Evaluation of the in-vivo activity and toxicity of amarogentin, an antileishmanial agent, in both liposomal and niosomal forms

Medda, Swapna ; Mukhopadhyay, Sibabrata ; Basu, Mukul Kumar (1999) Evaluation of the in-vivo activity and toxicity of amarogentin, an antileishmanial agent, in both liposomal and niosomal forms Journal of Antimicrobial Chemotherapy, 44 (6). pp. 791-794. ISSN 0305-7453

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Abstract

The antileishmanial property of amarogentin, a secoiridoid glycoside isolated from the Indian medicinal plant Swertia chirata, was examined in a hamster model of experimental leishmaniasis. The therapeutic efficacy of amarogentin was evaluated in free and two different vesicular forms, liposomes and niosomes. The amarogentin in both liposomal and niosomal forms was found to be a more active leishmanicidal agent than the free amarogentin; and the niosomal form was found to be more efficacious than the liposomal form at the same membrane microviscosity level. Toxicity studies involving blood pathology, histological staining of tissues and specific enzyme levels related to normal liver function showed no toxicity. Hence, amarogentin incorporated in liposomes or niosomes may have clinical application in the treatment of leishmaniasis.

Item Type:Article
Source:Copyright of this article belongs to Oxford University Press.
ID Code:1635
Deposited On:05 Oct 2010 12:10
Last Modified:16 May 2016 12:43

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