Alterations in atropine sites of the brain of rats as a function of age

James, T. C. ; Kanungo, M. S. (1976) Alterations in atropine sites of the brain of rats as a function of age Biochemical and Biophysical Research Communications, 72 (1). pp. 162-169. ISSN 0006-291X

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/000629...

Related URL: http://dx.doi.org/10.1016/0006-291X(76)90974-8

Abstract

Binding of (3H)-atropine to synaptosomal fractions prepared from cerebral and cerebellar cortices of young, adult and old male and female rats were studied. Picomoles of labelled atropine bound/mg protein was highest in the cerebral cortex of young rats and decreased with increasing age in both sexes, whereas in cerebellar cortex the peak binding was in adult rats. Acetylcholinesterase activity of the same fractions showed corresponding changes with age.

Item Type:Article
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ID Code:16333
Deposited On:15 Nov 2010 13:50
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