Synthesis of carbamyl and ether analogs of phosphatidylcholines

Agarwal, Kirti ; Bali, Anu ; Gupta, C. M. (1984) Synthesis of carbamyl and ether analogs of phosphatidylcholines Chemistry and Physics of Lipids, 36 (2). pp. 169-177. ISSN 0009-3084

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A complete synthesis of 1-O-hexadecyl-2-O-N-(heptadec-8-cis-enyl)carbamyl-sn-glycero-3-Phosphocholine, a novel analog of phosphatidylcholine, has been described. Each step is simple to perform and gives the desired products in high yield. Also, some of the intermediates formed during the synthesis have been efficiently utilized to prepare 1-O-hexadecyl-2-O-oleyl-sn-glycero-3-phosphocholine, 1-O-hexadecyl-2-oleoyl-sn-glycero-3-phosphochloine and 3-O-hexadecyl-2-oeloyl-sn-glycero-1-phosphocholine. These phosphatidylcholine (PC) analogs are useful for studying the possible role of phospholipases in the capture and lyses of liposomes in vivo.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Liposome; Drug Delivery; Plasma Lipoprotein; Phosphatidyl Analog; Phospholipases
ID Code:16009
Deposited On:16 Nov 2010 13:34
Last Modified:03 Jun 2011 04:50

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