Alternate view on thermal stability of the DNA duplex

Anil Kumar, (1995) Alternate view on thermal stability of the DNA duplex Biochemistry, 34 (40). pp. 12921-12925. ISSN 0006-2960

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Official URL: http://pubs.acs.org/doi/abs/10.1021/bi00040a001

Related URL: http://dx.doi.org/10.1021/bi00040a001

Abstract

A concept, based on the changes in internal pressure of water due to addition of salts, has been used to interpret the thermal stability of the DNA duplexes. Dependence of thermal stability of duplexes on the salt concentrations has also been described in terms of variations in the internal pressure of water observed in presence of ionic components. The thermal stabilities at high external pressures (up to 200 MPa) compared to those at atmospheric pressure are linearly related to the corresponding variations in internal pressures at several salt concentrations.

Item Type:Article
Source:Copyright of this article belongs to American Chemical Society.
ID Code:1599
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