Antibody-mediated targeting of liposomes to erythrocytes in the whole blood

Singhal, Arun ; Bali, Anu ; Gupta, C. M. (1986) Antibody-mediated targeting of liposomes to erythrocytes in the whole blood Biochimica et Biophysica Acta (BBA) - General Subjects, 880 (1). pp. 72-77. ISSN 0304-4165

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F(ab')2 fragments derived from anti-rat erythrocyte antibody or normal rabbit serum IgG were covalently attached to the surface of liposomes consisting of equimolar amounts of egg phosphatidylcholine and cholesterol. These liposomes were interacted with rat, monkey or mouse blood, and their binding to both red and white blood cells was determined. Results of these studies show that coupling of liposomes to anti-rat erythrocyte F(ab')2 considerably enhances their binding to erythrocytes in rat blood. However, no such increase in the binding was observed with rat leukocytes or monkey and mouse erythrocytes. Besides, the interactions between the liposomes and target cells did not affect the permeability properties of the liposome bilayer. These observations indicate that liposomes coupled to cell-specific antibodies may serve as highly useful carriers for homing of drugs/enzymes to specific cells in biophase.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Drug targeting; Liposome; Cell-specific antibody; F(ab')2 Fragment; (Erythrocyte)
ID Code:15984
Deposited On:16 Nov 2010 13:37
Last Modified:03 Jun 2011 04:47

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