Singhal, Arun ; Gupta, C. M. (1986) Antibody-mediated targeting of liposomes to red cells in vivo FEBS Letters, 201 (2). pp. 321-326. ISSN 0014-5793
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Official URL: http://dx.doi.org/10.1016/0014-5793(86)80632-9
Related URL: http://dx.doi.org/10.1016/0014-5793(86)80632-9
Abstract
Covalent attachment of anti-rat erythrocyte F(ab')2 to liposomes specifically enhanced their binding to rat erythrocytes in vivo and reduced their uptake by the liver. Furthermore, at least 20-30% of the cell-bound liposomes delivered their contents to the cells. Besides, the liposome binding did not affect the survival time of the target cells at least up to 3 h in the blood circulation. These results demonstrate for the first time that liposomes can be successfully targeted to cells other than liver cells in vivo.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Federation of European Biochemical Societies. |
| Keywords: | Drug targeting; LiposomeCell-specific; antibodyF(ab')2; Fragment (Erythrocyte) |
| ID Code: | 15982 |
| Deposited On: | 16 Nov 2010 13:37 |
| Last Modified: | 17 May 2016 00:49 |
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