A new look at nonparasitized red cells of malaria-infected monkeys

Gupta, C. M. ; Alam, A. ; Mathur, P. N. ; Dutta, G. P. (1982) A new look at nonparasitized red cells of malaria-infected monkeys Nature, 299 . pp. 259-261. ISSN 0028-0836

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Official URL: http://www.nature.com/nature/journal/v299/n5880/ab...

Related URL: http://dx.doi.org/10.1038/299259a0


Many reports have shown that malarial parasites can produce distinct morphological and molecular alterations in the membranes of the parasitized erythrocytes, but few studies have been carried out on nonparasitized erythrocytes of infected animals. We report here that the outer leaflet of the membrane bilayer of nonparasitized erythrocytes contains significantly larger amounts of aminophospholipids (phos-phatidylethanolamine (PE) and phosphatidylserine (PS)), than the normal red cell membrane. This alteration in nonparasitized red cells is probably caused by Ca2+-induced cross-linking of spectrin, and gradually disappears after chloroquine treatment. The external localization of PS in these cells together with defective structure of their cytoskeletal network provide a strong basis for the complications associated with malaria infection like thrombosis, infarction and severe anaemia.

Item Type:Article
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ID Code:15974
Deposited On:16 Nov 2010 13:38
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