New potent blood sugar lowering agent

Gupta, C. M. ; Hussain, S. T. ; Bhaduri, A. P. ; Khanna, N. M. ; Mukharjee, S. K. (1969) New potent blood sugar lowering agent Nature, 223 . p. 524. ISSN 0028-0836

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Hypoglycaemic activity has not so far been reported in any 4-quinazolone derivatives. We have found that 2-piperazino-3H,4-quinazolone monoacetate (I; 68/157) is an effective blood sugar lowering agent (patent pending). This compound was synthesized by heating 2-ethylthio-3H,4-quinazolone with N-benzylpiperazine followed by debenzylation with H2 over Pd/C in glacial acetic acid.

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