Chloroquine delivery to erythrocytes in Plasmodium berghei-infected mice using antibody-bearing liposomes as drug vehicles

Chandra, Subhash ; Agrawal, Ajay K. ; Gupta, C. M. (1991) Chloroquine delivery to erythrocytes in Plasmodium berghei-infected mice using antibody-bearing liposomes as drug vehicles Journal of Biosciences, 16 (3). pp. 137-144. ISSN 0250-5991

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Official URL: http://www.ias.ac.in/jarch/jbiosci/16/137-144.pdf

Related URL: http://dx.doi.org/10.1007/BF02703366

Abstract

Suitability of anti-erythrocyte F(ab')2-bearing liposomes as vehicles for chloroquine in the treatment of chloroquine resistantPlasmodium berghei infections in mice has been examined. Free chloroquine or chloroquine encapsulated in antibody-free liposomes failed to show much effect on the resistant infections, but the same doses of this drug after being encapsulated in antibody-bearing liposomes exhibited a significant inhibitory effect on this infection. These results indicate that chloroquine delivery in antibody targeted liposomes may help in the successful treatment of the chloroquine resistant malarial infections.

Item Type:Article
Source:Copyright of this article belongs to Indian Academy of Sciences.
Keywords:Drug Targeting; Liposomes; Antibody; Erythrocyte; Malaria; Drug-resistant Infection; Mice
ID Code:15947
Deposited On:16 Nov 2010 13:41
Last Modified:17 May 2016 00:47

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