Functional drug targeting to erythrocytes in vivo using antibody bearing liposomes as drug vehicles

Agrawal, Ajay K. ; Singhal, Arun ; Gupta, C. M. (1987) Functional drug targeting to erythrocytes in vivo using antibody bearing liposomes as drug vehicles Biochemical and Biophysical Research Communications, 148 (1). pp. 357-361. ISSN 0006-291X

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/000629...

Related URL: http://dx.doi.org/10.1016/0006-291X(87)91118-1

Abstract

Covalent attachment of anti-erythrocyte F(ab')2 to the liposome surface has recently been shown to considerably enhance the liposome binding to erythrocytes in vivo,. These antibody bearing liposomes have now been found quite effective as vehicles for delivering the antimalarial drug, chloroquine, to erythrocytes in Plasmodium, berghei-infected mice. This demonstrates the usefulness of antibody targeted liposomes as carriers for site-specific drug delivery.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:PC; Phosphatidylcholine
ID Code:15939
Deposited On:16 Nov 2010 13:42
Last Modified:03 Jun 2011 04:42

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