A novel route to methyl 3-(3,4-disubstituted 5-alkylthio/amino-2-thienyl) propenoates

Datta, A. ; Ila, H. ; Junjappa, H. (1988) A novel route to methyl 3-(3,4-disubstituted 5-alkylthio/amino-2-thienyl) propenoates Synthesis, 1988 (7). pp. 556-557. ISSN 0039-7881

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Official URL: https://www.thieme-connect.com/ejournals/abstract/...

Related URL: http://dx.doi.org/10.1055/s-1988-27638

Abstract

The 3-oxodithioesters 1 and 3-oxothioamides 6 are shown to undergo base catalyzed S-alkylation with methyl 4-bromocrotonate followed by intramolecular condensation to give the corresponding methyl 3-(3,4-disubstituted 5-alkylthio/amino-2-thienyl) propenoates 5 and 7 in good yields.

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