Conformational studies of antiradiation agents by NMR: cysteamine and its derivatives

Kulkarni, Vithal M. ; Govil, Girjesh (1977) Conformational studies of antiradiation agents by NMR: cysteamine and its derivatives Journal of Pharmaceutical Sciences, 66 (4). pp. 483-486. ISSN 0022-3549

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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/jps.260...

Related URL: http://dx.doi.org/10.1002/jps.2600660406

Abstract

The conformations of cysteamine, thiazolidine, and thia-zolidine-4-carboxylic acid were determined in aqueous solutions using NMR spectroscopy. At physiological pH, the population ratio of gauche- and trans- conformers was 3:1. The gauche-rotamer is probably responsible for the antiradiation activity and acts through metal chelation involving sulfur and nitrogen atoms. The puckering of the thiazolidine ring was calculated using NMR coupling constants. The observed results were compared with those obtained in the solid state using X-ray diffraction.

Item Type:Article
Source:Copyright of this article belongs to John Wiley and Sons, Inc.
Keywords:Cysteamine-and Derivatives; NMR Conformational Study in Aqueous Solutions; Thiazolidine-and Derivatives; NMR Conformational Study in Aqueous Solutions; NMR-conformational Study of Cysteamine; Thiazolidine, and Derivatives in Aqueous Solutions; Conformations-cysteamine; Thiazolidine; and Derivatives; NMR Study in Aqueous Solutions; Antiradiation Agents-cysteamine; Thiazolidine, and Derivatives; NMR Conformational Study in Aqueous Solutions
ID Code:15464
Deposited On:13 Nov 2010 14:26
Last Modified:14 Feb 2011 16:59

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