A facile route to 5-alkyl-1,1-bis(methylthio)penta-1,4-dien-3-ones

Asokan, C. V. ; Balu, M. P. ; Ila, H. ; Junjappa, H. (1988) A facile route to 5-alkyl-1,1-bis(methylthio)penta-1,4-dien-3-ones Synthesis, 1988 (9). pp. 727-729. ISSN 0039-7881

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Official URL: https://www.thieme-connect.com/ejournals/abstract/...

Related URL: http://dx.doi.org/10.1055/s-1988-27690

Abstract

(3-Dimethylamino-2-propenoyl)ketene dithioacetals 3a-c, obtained by condensation of the corresponding acylketene dithioacetals 1a-c with dimethylformamide diethyl acetal, undergo 1,4-additions with alkyl Grignard reagents (RMgX, R = CH3, C2H5, n-C3H7 and i-C3H7) on the enaminone moiety to afford the title compounds 4a-l in good yields.

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