Conformation and flexibility of the 3'-end of trna

Vasanth Kumar, N. ; Govil, Girjesh (1980) Conformation and flexibility of the 3'-end of trna International Journal of Quantum Chemistry, 18 (S7). pp. 101-113. ISSN 0020-7608

Full text not available from this repository.

Official URL:

Related URL:


A close examination of the crystal structure of tRNAPhe proposed by various groups reveals a great deal of discrepancy in the secondary structure of its acceptor end. The technique of energy minimization has been employed to study the preferred conformations and the flexibility of the pCpCpA fragment. Starting from various structures proposed for the -C-C-A end in tRNAPhe, the energy has been minimized as a function of 17 dihedral angles. A conformation where the terminal adenine is not stacked over the other two bases is found to be the most preferred conformation. This geometry is close to the refined structure proposed by the DUK group. Our results suggest a high degree of flexibility for the terminal adenosine unit in the -C-C-A segment. These findings are compared with the structure of -C-C-A in solution, as observed by nuclear magnetic resonance.

Item Type:Article
Source:Copyright of this article belongs to John Wiley and Sons, Inc.
ID Code:15412
Deposited On:13 Nov 2010 08:52
Last Modified:14 Feb 2011 11:19

Repository Staff Only: item control page