Acute hepatic failure due to Plasmodium falciparum liver injury

Joshi, Y. K. ; Tandon, B. N. ; Acharya, S. K. ; Babu, S. ; Tandon, M. (1986) Acute hepatic failure due to Plasmodium falciparum liver injury Liver, 6 (6). pp. 357-360. ISSN 0106-9543

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Nine patients with acute liver failure due to Plasmodium falciparum liver injury admitted to the Rajgarhia Liver Unit of the All-India Institute of Medical Sciences during 1982-84 are presented. The liver was palpable in all the patients, and eight had splenomegaly. Investigations revealed mild to moderate abnormality in liver function tests. All were negative for the markers of acute infection due to hepatitis A and B viruses. Blood film examination showed P. falciparum alone in seven and along with P. vivax in the remaining two patients. Liver histology, which was identical in all eight patients where liver biopsy was done, showed centrizonal necrosis and hyperplastic Kupffer cells loaded with malarial pigment. All the patients recovered with specific anti-malarial and supportive treatment. Our observations suggest that malaria due to P. falciparum may present as jaundice and encephalopathy which stimulates acute hepatic failure due to fulminant hepatitis.

Item Type:Article
Source:Copyright of this article belongs to John Wiley and Sons, Inc.
Keywords:Fulminant Hepatitis; Malaria; Plasmodium Falciparum Malaria
ID Code:154
Deposited On:17 Sep 2010 07:53
Last Modified:12 May 2011 04:24

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