Synthesis of novel 2-amino-4-aryl-5-arylthio-6-methoxypyrimidines and 3(5)-aryl-4-arylthio-5(3)-methylthiopyrazoles via α-oxo-α-arylthioketene dithioacetals

Singh, Gurdeep ; Deb, Biswajit ; Ila, Hiriyakkanavar ; Junjappa, Hiriyakkanavar (1987) Synthesis of novel 2-amino-4-aryl-5-arylthio-6-methoxypyrimidines and 3(5)-aryl-4-arylthio-5(3)-methylthiopyrazoles via α-oxo-α-arylthioketene dithioacetals Synthesis, 1987 (3). pp. 286-287. ISSN 0039-7881

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Official URL: https://www.thieme-connect.com/ejournals/abstract/...

Related URL: http://dx.doi.org/10.1055/s-1987-27920

Abstract

Reactions of α-arylthio-α-oxoketene dithioacetals 1 with guanidine nitrate in the presence of sodium methoxide in refluxing methanol afford novel 2-amino-4-aryl-5-arylthio-6-methoxy-pyrimidines. Similarly, when compounds 1 are reacted with hydrazine hydrate in refluxing ethanol, novel substituted 3(5)-aryl-4-arylthio-5(3) methylthiopyrazoles are obtained in high yields.

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