Bardos, T. J. ; Barua, A. K. ; Chmielewicz, Z. F. ; Crevar, G. E. ; Dailey, J. P. ; Divald, S. ; Papanastassiou, Z. B. (1965) Synthesis of potential dual antagonists III. Ring-substituted ethyl [bis(1-aziridinyl)phosphinyl] carbamates Journal of Pharmaceutical Sciences, 54 (2). pp. 187-190. ISSN 0022-3549
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Official URL: http://www3.interscience.wiley.com/journal/1132918...
Related URL: http://dx.doi.org/10.1002/jps.2600540205
The syntheses of a series of ring-substituted ethyl [bis(1-aziridinyl)phosphinyl]-carbamates are reported. Several of these compounds showed significant tumor inhibitory activities in experimental animals, and one of them, ethyl [bis(2,2-dimethyl-1-aziridinyl)phosphinyl]carbamate (AB-132), is currently under clinical investigation as an experimental antineoplastic agent.
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|Deposited On:||05 Oct 2010 17:51|
|Last Modified:||13 May 2011 15:36|
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