Direct synthesis of 2-(cycloalkylamino)-3,4-substituted thiophenes via selective deprotonation-cyclization of aroyl ketene N,S-acetals

Reddy, Kethiri R. ; Rao, Mandava V. Basaveswara ; Ila, Hiriyakkanavar ; Junjappa, Hiriyakkanavar (1996) Direct synthesis of 2-(cycloalkylamino)-3,4-substituted thiophenes via selective deprotonation-cyclization of aroyl ketene N,S-acetals Synthetic Communications, 26 (22). 4157- 4164. ISSN 0039-7911

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Related URL: http://dx.doi.org/10.1080/00397919608004653

Abstract

Acyclic and cyclic aroyl ketene N,S-acetals undergo regioselective deprotonation-cyclization via dipole stabilized carbanion in the presence of LDA/THF to afford the corresponding 2-(cycloalkylamino)-4-aryl or 3,4-annelated thiophenes in moderate to good yields.

Item Type:	Article
Source:	Copyright of this article belongs to Taylor and Francis Ltd.
ID Code:	15334
Deposited On:	13 Nov 2010 12:55
Last Modified:	17 May 2016 00:14

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