AmpliBASE MT: a Mycobacterium tuberculosis diversity knowledgebase

Majeed, Ahmed A. ; Ahmed, Niyaz ; Rajender Rao, K. ; Ghousunnissa, S. ; Kauser, Farhana ; Bose, Buddhaditta ; Nagarajaram, H. A. ; Katoch, V. M. ; Cousins, Debby V. ; Sechi, Leonardo A. ; Gilman, Robert H. ; Hasnain, Seyed E. (2004) AmpliBASE MT: a Mycobacterium tuberculosis diversity knowledgebase Bioinformatics, 20 (6). pp. 989-992. ISSN 1367-4803

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AmpliBASE MT is an online databank of high-resolution DNA fingerprints representing fluorescent amplified fragment length polymorphism (FAFLP) profiles or amplitypes developed for the Mycobacterium tuberculosis complex strains from 48 different countries. AmpliBASE MT is based on a relational database management system that is hyperlinked to visualize genotyping results in the form of DNA fingerprint images for individual strains. A flexible search system based on systematic comparisons of fragment sizes in base pairs allows inter-laboratory comparison of FAFLP profiles. Besides this, the database also displays previously published data on IS6110 profiles, spoligotypes, MIRU-VNTRs and large sequence polymorphisms along with the FAFLP records that will give the overall comparisons. Being the first of its kind, AmpliBASE MT is expected to be a very helpful tool in strengthening the concept of 'geographic genomics' and will be very helpful to molecular epidemiologists and those interested in diagnostic development for tuberculosis.

Item Type:Article
Source:Copyright of this article belongs to Oxford University Press.
ID Code:15259
Deposited On:13 Nov 2010 13:02
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