Nitric oxide inhibits enterocyte mitochondrial phospholipase D

Madesh, M. ; Balasubramanian, K. A. (1997) Nitric oxide inhibits enterocyte mitochondrial phospholipase D FEBS Letters, 413 (2). pp. 269-272. ISSN 0014-5793

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Mitochondrial damage is one of the prominent features of cell death in oxidative stress and related pathological conditions. Alteration in membrane lipid composition may be responsible for the mitochondrial damage. In this study, we have shown that intestinal mitochondria contain an active phospholipase D (PLD) which is activated by oxidants, Ca2+ or polyamines and this results in degradation of phosphatidylethanolamine (PE) and formation of phosphatidic acid (PA). This PLD activity is inhibited by nitric oxide (NO) which prevents the lipid alteration in mitochondria when exposed to these agents. This can be reversed by the NO scavenger, haemoglobin. This suggests that alteration of mitochondrial membrane lipid composition by activation of PLD in certain pathological condition such as oxidative stress may be prevented by the simultaneous presence of nitric oxide.

Item Type:Article
Source:Copyright of this article belongs to Federation of European Biochemical Societies.
Keywords:Phospholipase D; Enterocyte Mitochondria; Nitric Oxide; Phosphatidic Acid; Phosphatidylethanolamine
ID Code:1466
Deposited On:05 Oct 2010 12:27
Last Modified:16 May 2016 12:35

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