HBV genotypes in India: do they influence disease severity?

Madan, Kaushal ; Batra, Yogesh ; Sreenivas, Vishnubhatla ; Mizokami, Masashi ; Tanaka, Yasuhito ; Chalamalasetty, Sreenivasa Baba ; Panda, Subrat Kumar ; Acharya, Subrat K. (2009) HBV genotypes in India: do they influence disease severity? Hepatology Research, 39 (2). pp. 157-163. ISSN 1386-6346

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Official URL: http://www3.interscience.wiley.com/journal/1214291...

Related URL: http://dx.doi.org/10.1111/j.1872-034X.2008.00417.x


Aims: Association of HBV genotypes (especially A and D) with severity of liver disease is controversial. We studied the influence of HBV genotypes on liver disease severity among Indian patients. Methods: We selected 247 HBV infected patients (42 acute hepatitis, 87 carriers, 44 chronic hepatitis B [CHB], 35 liver cirrhosis [LC] and 40 hepatocellular carcinoma [HCC]). Genotyping of stored sera was performed using genotype-specific enzyme-linked immunosorbent assay (ELISA) and restriction fragment length polymorphism (RFLP). The distribution of genotypes in disease states of differing clinical, histological and biochemical severity were compared. Results: The most common genotype was D (162/237, 68.3%), followed by A (61, 25.7%) and C (14, 5.9%). The distribution of HBV genotypes between patients with acute hepatitis and CHB (carriers + CHB + LC + HCC), or between carriers and disease states (CHB + LC + HCC), or between mild chronic infection (carriers + CHB) and complications of chronic HBV infection (LC + HCC) was similar. Eighty-seven patients had liver biopsy; the median histological activity index (HAI) and fibrosis stage at baseline were similar between genotype groups (four [1-9] genotype A [n = 28]), three (2-4) genotype C (n = 4) and four (1-10) genotype D (n = 55); P = 0.33 for HAI score; (0.5 [0-6] genotype A, 0.5 [0-4] genotype C and 1 [0-6] genotype D; P = 0.92 for fibrosis stage). The response to therapy was similar between the genotypes. Conclusion: Clinical, histological severity and therapeutic responses are similar among patients with HBV genotypes A and D.

Item Type:Article
Source:Copyright of this article belongs to Japan Society of Hepatology.
Keywords:Chronic Hepatitis B; Genotype A; Genotype D; India; Severity
ID Code:145
Deposited On:17 Sep 2010 07:54
Last Modified:11 May 2011 07:05

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