Circulating antioxidants in ulcerative colitis and their relationship to disease severity and activity

Ramakrishna, B. S. ; Varghese, R. ; Jayakumar, S. ; Mathan, M. ; Balasubramanian, K. A. (1997) Circulating antioxidants in ulcerative colitis and their relationship to disease severity and activity Journal of Gastroenterology and Hepatology, 12 (7). pp. 490-494. ISSN 0815-9319

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Official URL: http://onlinelibrary.wiley.com/doi/10.1111/j.1440-...

Related URL: http://dx.doi.org/10.1111/j.1440-1746.1997.tb00471.x

Abstract

Oxygen free radicals produced by neutrophils are important in the pathogenesis of mucosal damage in ulcerative colitis. Vitamin A, vitamin E and cysteine in the plasma can scavenge free radicals. In the present study, plasma levels of vitamin A, vitamin E, cysteine, cystine and protein-bound cysteine were measured in active ulcerative colitis before and immediately after treatment of the active disease, and correlated with disease severity, extent and activity. Plasma vitamin A and cysteine were significantly reduced in active ulcerative colitis compared with controls. Levels of vitamin E, cystine and protein-bound cysteine were not significantly altered in active ulcerative colitis. Vitamin A and cysteine concentrations returned to normal levels (P < 0.05) within 2 weeks of treating active colitis. There were significant negative correlations between clinical severity and the plasma concentrations of vitamin A and cysteine. Plasma cysteine levels also correlated inversely to disease extent. Depletion of the circulating antioxidants, vitamin A and cysteine, in active ulcerative colitis is likely to be important in the pathophysiology of the disease.

Item Type:Article
Source:Copyright of this article belongs to John Wiley and Sons, Inc.
Keywords:Cysteine; Free Radicals; Ulcerative Colitis; Vitamin A
ID Code:1438
Deposited On:04 Oct 2010 11:19
Last Modified:14 May 2011 05:07

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