Magnitude of hepatitis C virus infection in India: prevalence in healthy blood donors, acute and chronic liver diseases

Panigrahi, Aswini K. ; Panda, Subrat K. ; Dixit, Rajesh K. ; Rao, Kanury V. S. ; Acharya, Subrat K. ; Dasarathy, Srinivasan ; Nanu, Ambika (1997) Magnitude of hepatitis C virus infection in India: prevalence in healthy blood donors, acute and chronic liver diseases Journal of Medical Virology, 51 (3). pp. 167-174. ISSN 0146-6615

Full text not available from this repository.

Official URL: http://www3.interscience.wiley.com/journal/46968/a...

Related URL: http://dx.doi.org/10.1002/(SICI)1096-9071(199703)51:3<167::AID-JMV5>3.0.CO;2-4

Abstract

An enzyme immunoassay (EIA) was developed in-house for the detection of anti-hepatitis C virus (HCV) antibody against the prevailing genotypes in India. The specific reactivity of the test was compared with commercial second and third-generation EIAs and reverse transcription nested polymerase chain reaction (RT-nested PCR). Fifteen thousand nine hundred twenty-two healthy blood donors at the All India Institute of Medical Sciences (AIIMS), New Delhi, India, were screened for anti-HCV antibody. Two hundred ninety-five (1.85%) of these donors were positive. The screening was also used to determine how many patients with acute hepatitis and chronic liver diseases were positive for anti-HCV antibody. Five hundred sixty-four chronic liver disease patients were screened for anti-HCV antibody and 78 (13.83%) were found positive. Two hundred forty-seven sporadic acute viral hepatitis patients were screened for viral infection markers. Hepatitis B and E viruses (HBV and HEV) were the major etiologic agents. HCV was associated with 9% of the acute cases. Anti-HCV core IgM with HCV RNA detection were found to be helpful for the diagnosis of acute HCV infection.

Item Type:Article
Source:Copyright of this article belongs to John Wiley and Sons, Inc.
Keywords:HCV; Anti-HCV prevalence; Blood Donors; Chronic Liver Disease; Acute Viral Hepatitis; IgM Antibody
ID Code:140
Deposited On:17 Sep 2010 07:55
Last Modified:14 Jun 2011 05:00

Repository Staff Only: item control page