Evaluation of an in situ forming hydrogel wound dressing based on oxidized alginate and gelatin

Balakrishnan, Biji ; Mohanty, M. ; Umashankar, P. R. ; Jayakrishnan, A. (2005) Evaluation of an in situ forming hydrogel wound dressing based on oxidized alginate and gelatin Biomaterials, 26 (32). pp. 6335-6342. ISSN 0142-9612

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S01429...

Related URL: http://dx.doi.org/10.1016/j.biomaterials.2005.04.012


Wound dressings that can be formed in situ offer several advantages over the use of preformed dressings such as conformability without wrinkling or fluting in the wound bed, ease of application and improved patient compliance and comfort. Here we describe such an in situ forming hydrogel wound dressing from gelatin, oxidized alginate and borax. Periodate oxidized alginate rapidly cross-links proteins such as gelatin in the presence of borax to give in situ forming hydrogels that are both non-toxic and biodegradable. The composite matrix has the haemostatic effect of gelatin, the wound healing-promoting feature of alginate and the antiseptic property of borax to make it a potential wound dressing material. The hydrogel was found to have a fluid uptake of 90% of its weight which would prevent the wound bed from accumulation of exudates. The water vapour transmission rate (WVTR) of the hydrogel was found to be 2686±124 g/m2/day indicating that the hydrogel can maintain a moist environment over wound bed in moderate to heavily exuding wound which would enhance epithelial cell migration during the healing process. The wound healing efficacy of hydrogel was evaluated in experimental full thickness wounds using a rat model which demonstrated that within 2 weeks, the wound covered with gel was completely filled with new epithelium without any significant adverse reactions. These in situ forming hydrogels fulfil many critical elements desirable in a wound dressing material.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Alginate; Gelatin; Cross-linking; Hydrogel; Wound Dressing; Wound Healing; In Vivo Test
ID Code:13751
Deposited On:12 Nov 2010 14:49
Last Modified:03 Jun 2011 09:36

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