Barium sulphate-loaded p(HEMA) microspheres as artificial emboli: preparation and properties

Jayakrishnan, A. ; Chithambara Thanoo, B. (1990) Barium sulphate-loaded p(HEMA) microspheres as artificial emboli: preparation and properties Biomaterials, 11 (7). pp. 477-481. ISSN 0142-9612

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/014296...

Related URL: http://dx.doi.org/10.1016/0142-9612(90)90061-T

Abstract

Poly(2-hydroxyethyl methacrylate) p(HEMA) microspheres of good spherical geometry (diameter 90-1500 μm) encapsulated with 40-50% barium sulphate to impart radiopaque properties were prepared by a solvent evaporation process. These microspheres were cross-linked by reacting with hexamethylene diisocyanate (HMDI) or by γ-irradiation in the presence of ethylene glycol dimethacrylate (EGDM) in n-heptane. Microspheres with a porous structure and a rough surface were also made by the incorporation of NaCI along with BaS04. The effects of concentration of the polymer solution, concentration of the stabilizing agent, concentration of BaS04, viscosity of the dispersion medium and ratio of the dispersed phase to the dispersion medium on the formation, stability and particle size distribution of the microspheres were investigated.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Microspheres; Radiopacity; BaS04 p(HEMA); Emboli
ID Code:13742
Deposited On:12 Nov 2010 15:01
Last Modified:03 Jun 2011 09:58

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