Developing dentate nucleus in man: a qualitative and quantitative study

Hayaran, A. ; Wadhwa, S. ; Gopinath, G. ; Bijlani, V. (1992) Developing dentate nucleus in man: a qualitative and quantitative study Experimental Brain Research, 89 (3). pp. 640-648. ISSN 0014-4819

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Histological and quantitative studies were carried out in dentate nucleus (DN) of 14 human fetuses of gestational ages ranging from 10 weeks to 28 weeks in Nissl stained sections. The dentate nucleus was already well delineated at 11 weeks, but the adult profile was attained only by 27-28 weeks. The magnocellular dorsomedial region and the parvocellular ventrolateral region became apparent at 17-18 weeks. The numerical density of neurons showed a steady decline with advancing gestational age. However, the absolute neuronal count until 19-20 weeks was 367.1 × 103 followed by a count of 249.5 × 103 at 22-23 weeks. The reduction in the count between the two periods was significant and coincided with cell death which was striking between 19 and 23 weeks. The glial cell population continued to increase with advancing gestational age. The occurrence of significant neuronal cell death and its probable role in the developing human DN is reported for the first time.

Item Type:Article
Source:Copyright of this article belongs to Springer-Verlag.
Keywords:Human Fetus; Dentate Nucleus; Neurons; Glia; Quantitation
ID Code:13623
Deposited On:12 Nov 2010 15:14
Last Modified:02 Jun 2011 04:53

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