Pareek, Siddhika ; Roy, Saugata ; Kumari, Bharti ; Jain, Pratistha ; Banerjee, Arup ; Vrati, Sudhanshu (2014) miR-155 induction in microglial cells suppresses Japanese encephalitis virus replication and negatively modulates innate immune responses Journal of Neuroinflammation, 11 (1). ISSN 1742-2094
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Official URL: http://doi.org/10.1186/1742-2094-11-97
Related URL: http://dx.doi.org/10.1186/1742-2094-11-97
Abstract
Microglial cells, which are resident macrophages of the central nervous system, play important roles in immune responses and pathogenesis. Japanese encephalitis virus (JEV) is a neurotropic virus that infects microglial cells in brain. Several microRNAs including miR-155 and miR-146a play an important role in defining the microglia inflammatory profile. In this study, we have investigated the effect of miR-155 and miR-146a modulation on JEV infection as well as innate immune responses in human microglial cells.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to BioMed Central Ltd. |
| ID Code: | 135830 |
| Deposited On: | 22 Aug 2023 11:33 |
| Last Modified: | 22 Aug 2023 11:33 |
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