Stereoselective Synthesis of 2-(2-Hydroxyalkyl)piperidine Alkaloids Through Prins–Ritter Reaction

Subba Reddy, B. V. ; Ghanty, Supriya ; Reddy, N. Siva Senkar ; Reddy, Y. Jayasudhan ; Yadav, J. S. (2014) Stereoselective Synthesis of 2-(2-Hydroxyalkyl)piperidine Alkaloids Through Prins–Ritter Reaction Synthetic Communications, 44 (11). pp. 1658-1663. ISSN 0039-7911

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Official URL: http://doi.org/10.1080/00397911.2013.869603

Related URL: http://dx.doi.org/10.1080/00397911.2013.869603

Abstract

A stereoselective total synthesis of the 2-(2-hydroxyalkyl)piperidine alkaloids has been accomplished by a Prins–Ritter amidation sequence. Other steps involved in this synthesis are Jacobsen's hydrolytic kinetic resolution (HRK) and ring-closing metathesis (RCM).

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