Banoth, Shivalal ; Kanikarapu, Suresh ; Yadav, Jhillu S. ; Mohapatra, Debendra K. (2016) Stereoselective synthesis of (+)-decarestrictine L using tandem isomerization followed by C–O and C–C bond formation reaction Tetrahedron Letters, 57 (39). pp. 4368-4370. ISSN 0040-4039
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Official URL: http://doi.org/10.1016/J.Tetlet.2016.08.055
Related URL: http://dx.doi.org/10.1016/J.Tetlet.2016.08.055
Abstract
A stereoselective synthesis of the (+)-decarestrictine L has been described following our own developed iodine-catalyzed tandem isomerization followed by C–O and C–C bond formation reaction for the construction of trans-2,6-disubstituted dihydropyran as the key step. Other important reactions used for this synthesis are 5-exo-trig-iodolactonization, Mitsunobu inversion, and Wacker’s oxidation. The total synthesis of the target molecule was achieved in 10 linear steps with 28% overall yield.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 135701 |
| Deposited On: | 10 Aug 2023 10:07 |
| Last Modified: | 10 Aug 2023 10:07 |
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