Gayke, Manoj ; Hirapara, Nirbhay ; Narode, Hanuman ; Bhosle, Siddhanath D. ; Bhosale, Rajesh S. ; Yadav, Jhillu Singh (2022) Zinc Chloride-Catalyzed Synthesis of Carbamates: An Application for the Synthesis of the Anti-Alzheimer’s Drug Rivastigmine ACS Omega, 7 (40). pp. 36017-36027. ISSN 2470-1343
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Official URL: http://doi.org/10.1021/acsomega.2c05350
Related URL: http://dx.doi.org/10.1021/acsomega.2c05350
Abstract
Herein, we report a synthetic protocol for the synthesis of carbamates by employing zinc chloride as a catalyst from carbamoyl chlorides and aromatic/aliphatic alcohols. The developed protocol successfully utilizes the gram-scale synthesis of the FDA-approved rivastigmine drug and its derivative. The utility of zinc chloride over other catalysts such as zinc dust and zinc acetate exhibits a 49-87% yield of carbamates.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 135655 |
| Deposited On: | 17 Jul 2023 07:22 |
| Last Modified: | 17 Jul 2023 07:22 |
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