Quadrifoglio, F. ; Manzini, G. ; Yathindra, N. ; Crea, R. (1983) Relative Stability of B and Z Structures in Oligodeoxynucleotides with Different Alternating Base Sequence and Length In: Nucleic Acids: The Vectors of Life.
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Official URL: https://link.springer.com/chapter/10.1007/978-94-0...
Abstract
The conformation of several oligodeoxynucleotides with alternating purine-pyrimidine sequences in aqueous salt solution has been studied by means of CD technique. Although the solution conditions should favor the Z-conformation, only C-G sequences are found in this structure. (G-C)n sequences with n up to 5 do not assume the left-handed conformation. The concatamer obtained with d(AT)3(CG)3 in high salt solution was found in B conformation whereas the concatamer obtained with d(TA)3(CG)3 in the same conditions showed alternating blocks of B and Z structures. The effect of base-stacking in this behavior is discussed.
| Item Type: | Conference or Workshop Item (Paper) |
|---|---|
| Source: | Copyright of this article belongs to Springer Nature Limited. |
| ID Code: | 135652 |
| Deposited On: | 17 Jul 2023 05:49 |
| Last Modified: | 17 Jul 2023 05:49 |
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