Pattern of nicotinamide nucleotides in the erythrocytes of pellagrins

Abstract

Nicotinamide nucleotides in the erythrocytes of normal human subjects and of patients suffering from pellagra were separated by paper chromatography and their concentrations determined. Though no differences were observed in the concentration of total nicotinamide nucleotides in erythrocytes of pellagrins and normals, significant differences were observed with regard to concentration of the individual nucleotides. The erythrocytes of pellagrins had significantly higher amounts of NMN than the erythrocytes of normal subjects, while levels of NAD and NADP tended to be lower in the pellagrins as compared to normals.