Influence of metabolic stress on translation of p53 isoforms

Khan, Debjit ; Chattopadhyay, Samit ; Das, Saumitra (2016) Influence of metabolic stress on translation of p53 isoforms Molecular & Cellular Oncology, 3 (1). e1039689. ISSN 2372-3556

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Official URL: http://doi.org/10.1080/23723556.2015.1039689

Related URL: http://dx.doi.org/10.1080/23723556.2015.1039689

Abstract

p53 and its isoforms are integral in modulating transcriptional gene expression programs and maintaining cellular homeostasis. We recently reported that glucose deprivation/caloric restriction induced translational control of p53 mRNA by scaffold/matrix attachment region binding-protein 1 (SMAR1), adding a cytoplasmic role of SMAR1 to its traditional nuclear role as a transcription factor.

Item Type:Article
Source:Copyright of this article belongs to Informa UK Limited
Keywords:IRES translation;mRNA;nutrient deprivation;p53;SMAR1;translational control
ID Code:134521
Deposited On:09 Jan 2023 03:35
Last Modified:09 Jan 2023 03:35

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