Ali, Firoj ; A., Anila H. ; Taye, Nandaraj ; Mogare, Devraj G. ; Chattopadhyay, Samit ; Das, Amitava (2016) Specific receptor for hydrazine: mapping the in situ release of hydrazine in live cells and in an in vitro enzymatic assay Chemical Communications, 52 (36). pp. 6166-6169. ISSN 1359-7345
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Official URL: http://doi.org/10.1039/c6cc01787h
Related URL: http://dx.doi.org/10.1039/c6cc01787h
Abstract
We report a new chemodosimetric reagent capable of detecting hydrazine in the presence of several other competing amine derivatives and ionic analytes of biological relevance. This reagent has been utilized for real time monitoring of in situ N2H4 release during the metabolism of a crucial tuberculosis drug, isoniazid, in live HepG2 cells. The fluorescence response of the reagent based on its specific reaction with N2H4 is used for developing an in vitro assay for aminoacylase-1.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Royal Society of Chemistry |
| ID Code: | 134479 |
| Deposited On: | 06 Jan 2023 10:27 |
| Last Modified: | 06 Jan 2023 10:27 |
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