An Efficient Route to Thieno[2,3-d]pyrimidine Derivatives by Tandem [2,3] and [3,3] Sigmatropic Rearrangement (SUPPORTING DATA)

Majumdar, Krishna ; Pal, Nilasish ; Chattopadhyay, Sudip (2006) An Efficient Route to Thieno[2,3-d]pyrimidine Derivatives by Tandem [2,3] and [3,3] Sigmatropic Rearrangement (SUPPORTING DATA) Letters in Organic Chemistry, 3 (9). pp. 709-711. ISSN 15701786

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Official URL: http://doi.org/10.2174/157017806778700033

Related URL: http://dx.doi.org/10.2174/157017806778700033

Abstract

Synthesis of biologically important thieno[2,3-d]pyrimidine derivatives 6a-f in 65-78% yields have been reported. The conditions applied here are based on the less studied tandem rearrangement protocol. The precursor sulfides in 73-85% were prepared from N,N-dimethyl-6-cholouracil and 1-aryloxy-4-chlorobut-2-yne by phase transfer catalyzed reaction condition.

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