Kumar, Krishan ; Moitra, Parikshit ; Bashir, Mohsin ; Kondaiah, Paturu ; Bhattacharya, Santanu (2020) Natural tripeptide capped pH-sensitive gold nanoparticles for efficacious doxorubicin delivery both in vitro and in vivo Nanoscale, 12 (2). pp. 1067-1074. ISSN 2040-3364
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Official URL: http://doi.org/10.1039/c9nr08475d
Related URL: http://dx.doi.org/10.1039/c9nr08475d
Abstract
Nanobiotechnology has been gaining ever-increasing interest for the successful implementation of chemotherapy based treatment of cancer. Gold nanoparticles (AuNPs) capped with a natural pH-responsive short tripeptide (Lys-Phe-Gly or KFG) sequence are presented herein for significant intracellular delivery of an anti-cancer drug, doxorubicin (DOX). A particularly increased apoptotic response has been observed for DOX treatments mediated by KFG-AuNPs when compared with drug alone treatments in various cell lines (BT-474, HeLa, HEK 293 T and U251). Furthermore, KFG-AuNP mediated DOX treatment significantly decreases cell proliferation and tumor growth in a BT-474 cell xenograft model in nude mice. In addition, KFG-AuNPs demonstrate efficacious drug delivery in DOX-resistant HeLa cells (HeLa-DOXR).
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Royal Society of Chemistry. |
| ID Code: | 134267 |
| Deposited On: | 05 Jan 2023 11:45 |
| Last Modified: | 05 Jan 2023 11:45 |
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