Vesicle and Stable Monolayer Formation from Simple “Click” Chemistry Adducts in Water

Bhattacharya, Santanu ; Biswas, Joydeep (2011) Vesicle and Stable Monolayer Formation from Simple “Click” Chemistry Adducts in Water Langmuir, 27 (5). pp. 1581-1591. ISSN 0743-7463

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Official URL: http://doi.org/10.1021/la104851g

Related URL: http://dx.doi.org/10.1021/la104851g

Abstract

Click chemistry has been successfully extended into the field of molecular design of novel amphiphatic adducts. After their syntheses and characterizations, we have studied their aggregation properties in aqueous medium. Each of these adducts forms stable suspensions in water. These suspensions have been characterized by dynamic light scattering (DLS) studies and transmission electron microscopy (TEM). The presence of inner aqueous compartments in such aggregates has been demonstrated using dye (methylene blue) entrapment studies. These aggregates have been further characterized using X-ray diffraction (XRD), which indicates the existence of bilayer structures in them. Therefore, the resulting aggregates could be described as vesicles. The temperature-induced order-to-disorder transitions of the vesicular aggregates and the accompanying changes in their packing and hydration have been examined using high-sensitivity differential scanning calorimetry, fluorescence anisotropy, and generalized polarization measurements using appropriate membrane-soluble probe, 1,6-diphenylhexatriene, and Paldan, respectively. The findings of these studies are consistent with each other in terms of the apparent phase transition temperatures. Langmuir monolayer studies confirmed that these click adducts also form stable monolayers on buffered aqueous subphase at the air-water interface.

Item Type:Article
Source:Copyright of this article belongs to American Chemical Society.
ID Code:134076
Deposited On:03 Jan 2023 11:33
Last Modified:03 Jan 2023 11:33

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