Yadav, Santosh K. ; Batra, Janendra K. (2015) Ribotoxin restrictocin manifests anti-HIV-1 activity through its specific ribonuclease activity International Journal of Biological Macromolecules, 76 . pp. 58-62. ISSN 0141-8130
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Official URL: http://doi.org/10.1016/j.ijbiomac.2015.01.062
Related URL: http://dx.doi.org/10.1016/j.ijbiomac.2015.01.062
Abstract
Restrictocin, a highly specific ribonuclease produced by Aspergillus restrictus, cleaves a single phosphodiester bond in a universally conserved stem and loop structure termed sarcin/ricin loop within the large ribosomal RNA of all organisms. In the current study, we demonstrate restrictocin to manifest anti-HIV-1 activity in two model cell systems. Using two mutants of restrictocin, we further show that the anti-HIV-1 activity of restrictocin is due to its specific ribonucleolytic activity. The study suggests that restrictocin is able to recognize region(s) within HIV-1 genome as its target. Restrictocin appears to have potential as a therapeutic antiviral agent against HIV-1.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 133236 |
| Deposited On: | 27 Dec 2022 08:47 |
| Last Modified: | 27 Dec 2022 08:47 |
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