A case-control study for differences among hepatitis B virus infections of genotypes A (subtypes Aa and Ae) and D

Tanaka, Yasuhito ; Hasegawa, Izumi ; Kato, Takanobu ; Orito, Etsuro ; Hirashima, Noboru ; Acharya, Subrat K. ; Gish, Robert G. ; Kramvis, Anna ; Kew, Michael C. ; Yoshihara, Namiko ; Shrestha, Santosh Man ; Khan, Mobin ; Miyakawa, Yuzo ; Mizokami, Masashi (2004) A case-control study for differences among hepatitis B virus infections of genotypes A (subtypes Aa and Ae) and D Hepatology, 40 (3). pp. 747-755. ISSN 0270-9139

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Official URL: http://www3.interscience.wiley.com/journal/1096063...

Related URL: http://dx.doi.org/10.1002/hep.20365


There are two subtypes of hepatitis B virus genotype A (HBV/A) and they are provisionally designated Aa (a standing for Africa/Asia) and Ae (e for Europe). In a case-control study, 78 HBV/Aa, 78HBV/Ae, and 78HBV/D carriers from several countries were compared. The prevalence of HBe antigen (HBeAg) in serum was significantly lower in carriers of HBV/Aa than in carriers of HBV/Ae (31% vs. 49%; P = .033), with a difference more obvious in the carriers aged 30 years or younger (34% vs. 67%; P = .029). HBV DNA levels in the carriers of HBV/Aa (median, 3.46 log copies/mL; 95% CI, 2.93-3.95) were significantly lower than those of carriers of HBV/Ae (6.09 log copies/mL; 95% CI, 4.24-7.64) or of carriers of HBV/D (5.48 log copies/mL; 95% CI, 4.06-7.02), regardless of the HBeAg status (P < .001). The most specific and frequent substitutions in 54 HBV/Aa isolates were double substitutions for T1809 (100%) and T1812 (96%) immediately upstream of the precore initiation codon, which would interfere with the translation of HBeAg in HBV/Aa infections. They were not detected in 57 HBV/Ae or 61 HBV/D isolates examined. The double mutation in the core promoter (T1762/A1764) was more frequent in both HBV/Aa (50%) and HBV/Ae (44%) than in HBV/D isolates (25%; P < .01), whereas the precore mutation (A1896) occurred in HBV/D isolates only (48%; P < .0001). In conclusion, the clearance of HBeAg from serum may occur by different mechanisms in HBV/Aa, HBV/Ae, and HBV/D infections, which may influence clinical manifestations in the Western countries where both genotypes A and D are prevalent.

Item Type:Article
Source:Copyright of this article belongs to American Association for the Study of Liver Diseases.
ID Code:132
Deposited On:17 Sep 2010 06:59
Last Modified:16 May 2016 11:24

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