Sekar, Govindasamy ; Badigenchala, Sindhura ; Ganapathy, Dhandapani ; Das, Ankita ; Singh, Rahul (2013) Iron(II) Chloride–1,1′-Binaphthyl-2,2′-diamine (FeCl2–BINAM) Complex Catalyzed Domino Synthesis of Bisindolylmethanes from Indoles and Primary Alcohols Synthesis, 46 (01). pp. 101-109. ISSN 0039-7881
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Official URL: http://doi.org/10.1055/s-0033-1340052
Related URL: http://dx.doi.org/10.1055/s-0033-1340052
Abstract
Biologically important bisindolylmethanes are synthesized in a domino fashion by using an iron(II) chloride–(±)-1,1′-binaphthyl-2,2′-diamine [FeCl2–(±)-BINAM] complex as the catalyst. This method proceeds via oxidation of a primary alcohol into the corresponding aldehyde followed by nucleophilic addition of an indole in the presence of the catalyst. A reaction intermediate is synthesized separately and converted into the bisindolylmethane product under the same reaction conditions as support for the proposed mechanism.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Thieme Medical Publishers Inc. |
| Keywords: | bisindolylmethanes; iron catalysts; alcohol oxidation; domino reactions; BINAM ligand |
| ID Code: | 131750 |
| Deposited On: | 08 Dec 2022 05:25 |
| Last Modified: | 08 Dec 2022 05:25 |
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