Rajeshkumar, Venkatachalam ; Chandrasekar, Selvaraj ; Sekar, Govindasamy (2014) An efficient route to synthesize isatins by metal-free, iodine-catalyzed sequential C(sp3)–H oxidation and intramolecular C–N bond formation of 2′-aminoacetophenones Organic and Biomolecular Chemistry, 12 (42). pp. 8512-8518. ISSN 1477-0520
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Official URL: http://doi.org/10.1039/c4ob01564a
Related URL: http://dx.doi.org/10.1039/c4ob01564a
Abstract
A novel molecular I2-catalyzed synthesis of isatins through C(sp3)–H oxidation and intramolecular C–N bond formation of 2′-aminoacetophenones with excellent yields up to 97% under transition metal, base, additive, peroxide and ligand free conditions is described. The present protocol is suitable for gram scale synthesis of isatins and retained its high yield. Further, the synthetic utility of this present reaction towards synthesis of bioactive 3-hydroxy-2-oxindoles and oxindoles is demonstrated.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to The Royal Society of Chemistry. |
| ID Code: | 131573 |
| Deposited On: | 07 Dec 2022 07:27 |
| Last Modified: | 07 Dec 2022 07:27 |
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