Highly stereoselective approach for β-hydroxy-α-amino acids from d-glucose : The synthesis of MeBmt

Abstract

A highly stereoselective protocol for the synthesis of β-hydroxy-α-amino acids from glucofuranose has been developed which has culminated in stereospecific synthesis of MeBmt - an unusual aminoacid component of immunosuppressive peptide cyclosporin. A stereospecific synthesis of MeBmt, an unusual amino acid present in the clinically used immunosuppressive agent - Cyclosporin, is described.